21 CFR §1305.15

1. (a)A DEA Form 222 must not be filled if either of the following apply:
   1. (1)The order is not complete, legible, or properly prepared, executed, or endorsed.
   2. (2)The order shows any alteration, erasure, or change of any description.
2. (b)If a DEA Form 222 cannot be filled for any reason under this section, the supplier must return the original DEA Form 222 to the purchaser with a statement as to the reason (e.g., illegible or altered).
3. (c)A supplier may for any reason refuse to accept any order and if a supplier refuses to accept the order, a statement that the order is not accepted is sufficient for purposes of this paragraph.
4. (d)When a purchaser receives an unaccepted order, the original DEA Form 222 and the statement must be retained in the files of the purchaser in accordance with § 1305.17. A defective DEA Form 222 may not be corrected; it must be replaced by a new DEA Form 222 for the order to be filled.