21 CFR §1314.42

1. (a)A regulated seller must pay a fee for each self-certification. For each initial application to self-certify, and for the renewal of each existing self-certification, a regulated seller shall pay a fee of $21.
2. (b)The fee for self-certification shall be waived for any person holding a current, DEA registration in good standing as a pharmacy to dispense controlled substances.
3. (c)A regulated seller shall pay the fee at the time of self-certification.
4. (d)Payment shall be made by credit card.
5. (e)The self-certification fee is not refundable.