21 CFR §170.245
Verified against eCFR.gov as of June 20, 2026View official text on eCFR.gov ↗
If the statutory basis for your conclusion of GRAS status is through experience based on common use in food, in Part 5 of your GRAS notice you must include evidence of a substantial history of consumption of the notified substance for food use by a significant number of consumers prior to January 1, 1958.