StacksVerified U.S. regulatory reference

21 CFR §529.778

Verified against eCFR.gov as of June 20, 2026View official text on eCFR.gov ↗
  1. (a)Specifications. Doxycycline hyclate solution contains 8.5 percent doxycycline activity. A syringe of N-methyl-2-pyrrolidone and poly (DL-lactide) mixed with a syringe of doxycycline produces 0.5 milliliter of solution.
  2. (b)Sponsor. See 054771 in § 510.600(c) of this chapter.
  3. (c)Conditions of use in dogs—(1) Amount. Apply subgingivally to periodontal pocket(s) of affected teeth.
    1. (2)Indications for use. For treatment and control of periodontal disease.
    2. (3)Limitations. Federal law restricts this drug to use by or on the order of a licensed veterinarian.