StacksVerified U.S. regulatory reference

21 CFR §558.625

Verified against eCFR.gov as of June 20, 2026View official text on eCFR.gov ↗
  1. (a)Specifications. Type A medicated articles containing tylosin phosphate.
  2. (b)Sponsors. See sponsor numbers in § 510.600(c) of this chapter.
    1. (1)No. 016592: Type A medicated articles containing 40 or 100 grams per pound (g/lb).
    2. (2)No. 054771: Type A medicated article containing 40 g/lb.
    3. (3)No. 058198: Type A medicated articles containing 10, 40, or 100 g/lb.
    4. (4)No. 066104: Type A medicated articles containing 20 or 40 g/lb.
  3. (c)Related tolerances. See § 556.746 of this chapter.
  4. (d)Special considerations.
    1. (1)Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian. See § 558.6 for additional requirements.
    2. (2)The expiration date of VFDs for tylosin medicated feeds must not exceed 6 months from the date of issuance. VFDs for tylosin shall not be refilled.
    3. (3)Type C medicated feeds for cattle may be manufactured from tylosin liquid Type B medicated feeds which have a pH between 4.5 and 6.0 and which bear appropriate mixing directions as follows:
      1. (i)For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used.
      2. (ii)For liquid feeds stored in mechanical, air, or other agitation-type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used.
    4. (4)Tylosin liquid Type B medicated feeds must bear an expiration date of 31 days after the date of manufacture.
    5. (5)Do not use tylosin liquid Type B medicated feeds in any liquid feed containing sodium metabisulfite or in any finished feed (supplement, concentrate, or complete feed) containing in excess of 2 percent bentonite.
  5. (e)Conditions of use—(1) Swine—
    1. (2)Cattle—