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    CAS
registry No.
A. Toxic Chemicals:
1. Family: O-Alkyl(≤C10, incl. cycloalkyl) alkyl (Me, Et, n-Pr or i-Pr)- phosphonofluoridates
Not limited to the following examples:
Sarin: O-Isopropyl methylphosphonofluoridate 107-44-8
Soman: O-Pinacolyl methylphosphonofluoridate 96-64-0
2. Family: O-Alkyl (≤C10, incl. cycloalkyl) N,N-dialkyl (Me, Et, n-Pr or i-Pr) phosphoramidocyanidates
Not limited to the following example:
Tabun: O-Ethyl N,N-dimethyl phosphoramidocyanidate 77-81-6
3. Family: O-Alkyl (H or ≤C10, incl. cycloalkyl) S-2-dialkyl (Me, Et, n-Pr or i-Pr)-aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonothiolates and corresponding alkylated or protonated salts
Not limited to the following example:
VX: O-Ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate 50782-69-9
4. Sulfur mustards:
2-Chloroethylchloromethylsulfide 2625-76-5
Mustard gas: Bis(2-chloroethyl)sulfide 505-60-2
Bis(2-chloroethylthio)methane 63869-13-6
Sesquimustard: 1,2-Bis(2-chloroethylthio)ethane 3563-36-8
1,3-Bis(2-chloroethylthio)-n-propane 63905-10-2
1,4-Bis(2-chloroethylthio)-n-butane 142868-93-7
1,5-Bis(2-chloroethylthio)-n-pentane 142868-94-8
Bis(2-chloroethylthiomethyl)ether 63918-90-1
O-Mustard: Bis(2-chloroethylthioethyl)ether 63918-89-8
5. Lewisites:
Lewisite 1: 2-Chlorovinyldichloroarsine 541-25-3
Lewisite 2: Bis(2-chlorovinyl)chloroarsine 40334-69-8
Lewisite 3: Tris(2-chlorovinyl)arsine 40334-70-1
6. Nitrogen mustards:
HN1: Bis(2-chloroethyl)ethylamine 538-07-8
HN2: Bis(2-chloroethyl)methylamine 51-75-2
HN3: Tris(2-chloroethyl)amine 555-77-1
7. Saxitoxin 35523-89-8
8. Ricin 9009-86-3
13. Family: Р-alkyl (H or ≤C10, incl. cycloalkyl) N-(1-(dialkyl(≤C10, incl. cycloalkyl)amino))alkylidene(H or ≤C10, incl. cycloalkyl) phosphonamidic fluorides and corresponding alkylated or protonated salts
Not limited to the following examples:
N-(1-(di-n-decylamino)-n-decylidene)-P-decylphosphonamidic fluoride 2387495-99-8
Methyl-(1-(diethylamino)ethylidene)phosphonamidofluoridate 2387496-12-8
14. Family: O-alkyl (H or ≤C10, incl. cycloalkyl) N-(1-(dialkyl(≤C10, incl. cycloalkyl)amino))alkylidene(H or ≤C10, incl. cycloalkyl) phosphoramidofluoridates and corresponding alkylated or protonated salts
Not limited to the following examples:
O-n-Decyl N-(1-(di-n-decylamino)-n decylidene)phosphoramidofluoridate 2387496-00-4
Methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate 2387496-04-8
Ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate 2387496-06-0
15. Methyl-(bis(diethylamino)methylene)phosphonamidofluoridate 2387496-14-0
16. Carbamates (quaternaries and bisquaternaries of dimethylcarbamoyloxypyridines)
16.1. Family: Quaternaries of dimethylcarbamoyloxypyridines: 1-[N,N-dialkyl(≤C10)-N-(n-(hydroxyl, cyano, acetoxy)alkyl(≤C10)) ammonio]-n-[N-(3-dimethylcarbamoxy-α-picolinyl)-N,N-dialkyl(≤C10) ammonio]decane dibromide (n=1-8)
Not limited to the following example:
1-[N,N-dimethyl-N-(2-hydroxy)ethylammonio]-10-[N-(3-dimethylcarbamoxy-α-picolinyl)-N,N-dimethylammonio]decane dibromide 77104-62-2
16.2. Family: Bisquaternaries of dimethylcarbamoyloxypyridines:1,n-Bis[N-(3-dimethylcarbamoxy-α-picolyl)-N,N-dialkyl(≤C10) ammonio]-alkane-(2,(n-1)-dione) dibromide (n=2-12)
Not limited to the following example:
1,10-Bis[N-(3-dimethylcarbamoxy-α-picolyl)-N-ethyl-N- methylammonio]decane-2,9-dione dibromide 77104-00-8
B. Precursors:
9. Family: Alkyl (Me, Et, n-Pr or i-Pr) phosphonyldifluorides
Not limited to the following example:
DF: Methylphosphonyldifluoride 676-99-3
10. Family: O-Alkyl (H or ≤C10, incl. cycloalkyl) O-2-dialkyl (Me, Et, n-Pr or i-Pr)-aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonites and corresponding alkylated or protonated salts
Not limited to the following example:
QL: O-Ethyl O-2-diisopropylaminoethyl methylphosphonite 57856-11-8
11. Chlorosarin: O-Isopropyl methylphosphonochloridate 1445-76-7
12. Chlorosoman: O-Pinacolyl methylphosphonochloridate 7040-57-5

Notes to Supplement No. 1

Note 1: Note that the following Schedule 1 chemicals are controlled for export purposes under the Export Administration Regulations (see part 774 of the EAR, the Commerce Control List): Saxitoxin (35523-89-8) and Ricin (9009-86-3).

Note 2: All Schedule 1 chemicals not listed in Note 1 to this Supplement are controlled for export purposes by the Directorate of Defense Trade Controls of the Department of State under the International Traffic in Arms Regulations (22 CFR parts 120 through 130).

Note 3: The numerical sequence of the “Schedule 1” Toxic Chemicals and Precursors is not consecutive so as to align with the December 23, 2019, consolidated textual changes to “Schedule 1” of the Annex on Chemicals to the Chemical Weapons Convention (CWC), which reflect the decisions adopted by the CWC Conference of the States Parties in November 2019.

[71 FR 24929, Apr. 27, 2006, as amended at 86 FR 941, Jan. 7, 2021]


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