21 CFR § 1302.06
Sealing of controlled substances
June 25, 2020
On each bottle, multiple dose vial, or other commercial container of any controlled substance, there shall be securely affixed to the stopper, cap, lid, covering, or wrapper or such container a seal to disclose upon inspection any tampering or opening of the container.
[62 FR 13958, Mar. 24, 1997]
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